性别和化对输血依赖性β-thalassaemia中的ferritin-肝功能测试关系的影响
Radhwan M Hussein1, Zahraa Alaa Alrufaei2, Muntadher Zmezim3
1Department of Clinical Laboratory Sciences, Ahl Al Bayt University, Karbala, Iraq.
European journal of hospital pharmacy : science and practice
|January 14, 2026
概括
性别和结合疗法显著影响肝功能测试 (LFT) 和输血依赖β-血症 (TDT) 的费里丁水平. 酸氨基转移酶 (AST) 一致预测费里丁,在女性和特定治疗组中观察到差异.
科学领域:
- 血液学 血液学 血液学
- 肝病学 肝病学是一种肝病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 输血依赖性β-血症 (TDT) 需要终身输血,导致铁过载和肝损伤.
- 血清费里丁和肝功能测试 (LFTs) 是监测铁负荷和肝损伤的关键标志物.
- 在TDT中,性别,化方案和这些生化标志物的相互作用尚未得到充分理解.
研究的目的:
- 在一个大型的伊拉克TDT队列中调查血清费里和LFT之间的关联.
- 探索性别和化方案对费里丁-LFT关系的影响.
- 为了确定TDT患者中费里水平升高的预测因子.
主要方法:
- 在伊拉克对323名TDT患者进行了回顾性横截面研究.
- 数据收集包括人口统计,费里丁,LFTs,输血史和化疗法.
- 统计分析涉及曼-惠特尼U,费舍尔的确切,斯皮尔曼的相关性,多重线性回归和ROC分析.
主要成果:
- 在费里丁与AST (ρ=0.581) 和ALT (ρ=0.516) 之间发现了强烈的正相关性.
- 性别特定的分析揭示了女性与胆红素和ALP的额外关联.
- 与单独使用deferasirox相比,联合结合疗法 (deferasirox + deferoxamine) 与更高的费里丁,AST和ALT有关.
结论:
- 性别和化疗法在TDT中显著改变了费里丁-LFT关系.
- AST是跨组可靠的费里丁预测剂,而胆红素和相互作用术语在特定子组中很重要.
- 基于性别和治疗的生物化学标志物的定制解释对于管理TDT患者至关重要.
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