流动框架:一个全血管在芯片上的平台,用于建模系统性疾病,并指导全血管干预装置合适的协调性
Lingsen You1, Yuheng Chen2, Zeyang Zhang2
1Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China; National Clinical Research Center for Interventional Medicine, Shanghai 200032, China; University of Shanghai for Science and Technology (USST), Oriental Pan-Vascular Devices Innovation College, Shanghai 200093, China; State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai 200032, China.
一个新的全血管在芯片 (OoC) 平台,FLOW,模拟复杂的动脉样硬化驱动疾病,并评估干预设备. 这种器官在芯片上的技术改善了设备与血管的相互作用,以更好地治疗心血管疾病.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 芯片上的器官技术
背景情况:
- 由动脉样硬化驱动的泛血管疾病是全球死亡的主要原因.
- 现有的模型缺乏高保真性血液动力学,长期监测和3D动态交互来开发干预器件.
- 建模的挑战包括这些疾病的长期多器官性质和复杂的器械血管相互作用.
研究的目的:
- 引入FLOW (忠实性血液动力学重建,纵向生理监测,全血管床建模,全空间3D交互式工作流) 框架,这是一个全血管在芯片上的新平台.
- 为了实现全血管病理的高准确度建模,并促进干预设备的优化.
- 解决目前用于研究动脉样硬化驱动疾病的体外和体内模型的局限性.
主要方法:
- 开发了FLOW框架,整合了四个模块:血液动力学重建,纵向监测,多血管床建模和3D交互式工作流.
- 利用器官在芯片 (OoC) 技术与微流体,实时传感,细胞工程和基于水凝的设计.
- 应用"套装"概念来评估设备与容器的相互作用.
主要成果:
- 流动平台使动脉样硬化引起的疾病 (如心肌梗塞,中风) 和血栓形成的高准确度建模.
- 有助于优化干预设备,如支架,门和血栓切除导管.
- 在干预后显示出重新平衡生物机械,细胞和物理化学免疫生态的潜力.
结论:
- 泛血管在芯片上的方法,以FLOW平台为例,是研究动脉样硬化和开发干预设备的范式转变工具.
- 这项技术增强了对器件-血管和的理解,并有助于对抗心血管疾病.
- 未来的前景包括多器官集成,人工智能驱动的分析和个性化医疗应用.
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