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相关概念视频

Smooth Muscle Contraction01:25

Smooth Muscle Contraction

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Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
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The Role of Actin and Myosin in Non-muscle Cells01:10

The Role of Actin and Myosin in Non-muscle Cells

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Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They  are held...
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相关实验视频

Updated: Jan 17, 2026

Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues
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在三维工程肌肉中TNF-α诱导的收缩功能障碍.

Yukinori Tamura1, Junpei Ishizaka1, Sho Yokoyama2

  • 1Division of Physiology and Biochemistry, Faculty of Nutrition, Kobe Gakuin University, 518 Arise, Ikawadani-cho, Nishi-ku, Kobe 651-2180, Japan.

Journal of bioscience and bioengineering
|January 14, 2026
PubMed
概括

瘤亡因子-α (TNF-α) 通过破坏其结构和收缩功能,显著削弱工程肌肉. 这种细胞因子会损害细胞外基质,体和信号传递,从而提供了对肉类的机制的见解.

关键词:
信号传递的.激发收缩的合器细胞外矩阵是一个细胞外矩阵.肌肉疲弱 肌肉疲弱 肌肉疲弱三维工程肌肉是三维工程肌肉.瘤死亡因子-α

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相关实验视频

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科学领域:

  • 肌肉生理学 肌肉生理学
  • 生物医学工程 生物医学工程
  • 炎症研究的研究.

背景情况:

  • 骨肌肉疲软是诸如缩症和缓解症等疾病的标志.
  • 瘤亡因子-α (TNF-α) 与肌肉衰弱有关,但其直接机制尚未完全理解.
  • 三维工程肌肉 (3D-EM) 为研究肌肉功能提供了一个生理学上相关的模型.

研究的目的:

  • 调查TNF-α对3D-EM收缩力的直接影响.
  • 阐明TNF-α诱导肌肉衰弱的分子和结构机制.

主要方法:

  • 使用C2C12神经细胞和I型原体创建了3D-EM结构.
  • 结构被用TNF-α治疗,并通过电脉冲刺激测量收缩力.
  • 免疫组织化学和RNA测序 (RNA-seq) 用于分析结构和转录组变化.

主要成果:

  • 治疗TNF-α导致48小时后收缩力减少60%,72小时后减少90%.
  • 免疫组织化学检查显示了肌管缩和快速缩纤维的损失.
  • RNA-seq分析表明与细胞外基质,瘤组织和信号传递相关的抑制途径.

结论:

  • 在3D-EM中,TNF-α通过破坏细胞外矩阵完整性,体结构和依赖的收缩来损害3D-EM中的力生成.
  • 快速抽的肌肉纤维优先受到TNF-α的影响.
  • 3D-EM作为一种有价值的模型,用于理解细胞因子诱导的肌肉衰弱和肉症.