在患有自闭症谱系障碍的儿童中治疗焦虑和感官过敏的一种新型共生药物 (SCM06):一项开放标签试点研究
Oscar W H Wong1,2, Zhilu Xu3,4, Sandra S M Chan1,2
1Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong SAR, China.
NPJ biofilms and microbiomes
|January 14, 2026
概括
一种新型的共生菌,SCM06,在改善自闭症谱系障碍 (ASD) 儿童的焦虑和感官问题方面表现有前途. 治疗是安全的,耐受性很好,肠道细菌的变化与缓解症状有关.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 儿科 儿科 儿科
背景情况:
- 在患有自闭症谱系障碍 (ASD) 的儿童中,焦虑和感官过度反应很普遍.
- 目前对ASD中这些症状的治疗方法有限.
- 微生物群-肠-大脑轴是一个潜在的治疗目标.
研究的目的:
- 评估SCM06的安全性和有效性,一种新型共生菌,在患有ASD的儿童中.
- 评估SCM06对焦虑,感官反应过敏和腹部疼痛的影响.
- 探索肠道微生物群变化与症状改善之间的关系.
主要方法:
- 一项开放式试点研究涉及30名患有自闭症儿童 (平均年龄8.2岁).
- 对SCM06进行12周的治疗,并对症状,遵从性和安全性进行评估.
- 收集便样本进行元基因组和代谢组分析.
主要成果:
- 发现SCM06在研究人群中是安全的和耐受性的.
- 在焦虑,感官反应过敏和腹部疼痛方面观察到显著改善.
- 增加Bifidobacterium pseudocatenulatum丰富度与减少腹部疼痛相关;和黄油酸水平上升.
结论:
- SCM06显示出作为治疗药物来治疗患有自闭症儿童焦虑和感官问题的潜力.
- 肠道微生物的转变,包括特定的物种和代谢物,可能会调解症状的改善.
- 需要进一步的随机对照试验来确认SCM06.06的临床有效性.
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