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Updated: Jun 1, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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基于基因组挖掘的发现,一种非典型的真菌非还原性聚基酸合成酶编码二次性基醇生物合成

Yuto Homma1, Tomoya Hasegawa1, Yohei Morishita1

  • 1Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

The Journal of antibiotics
|January 14, 2026
PubMed
概括

基因组挖掘发现了一种新型的真菌基因集群,产生二次性基酸. 这一发现揭示了二元化必不可少的独特的多基酸合成酶机制,为整合素生物合成提供了洞察力.

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