在妇科外科瘤学中以探针为基础的同焦激光内显微镜:用于指导外科切除手术的手术内见解
Stefano Ferla1,2, Stefano Fucina3, Nicolò Clemente4
1Division of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero - Universitaria di Bologna, Bologna, Italy.
Annals of surgical oncology
|January 14, 2026
概括
基于探针的共聚焦激光内显微镜 (pCLE) 显示了在手术内卵巢癌评估的组织学高一致性. 这种实时成像工具通过在手术现场直接对组织进行快速表征,有助于手术决策.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术技术 手术技术
- 医疗成像医学成像
背景情况:
- 卵巢癌是女性癌症相关死亡的主要原因,细胞减小手术作为主要治疗方法.
- 术内组织分化至关重要,但传统上依赖于冷截面分析.
- 新的实时光学成像技术正在开发中,以加强外科手术决策.
研究的目的:
- 在外科病例中展示基于探针的共聚焦激光内分显微镜 (pCLE) 的逐步程序.
- 评估PCLE作为在卵巢癌手术中实时组织表征的手术内工具的潜力.
主要方法:
- pCLE使用连接到Cellvizio®系统的GastroFlexTM UHD聚焦迷你探针TM进行.
- 在两个手术中,在注射光素后获得实时显微镜图像.
- pCLE发现与随后组织活检的组织学分析进行了比较.
主要成果:
- 正常的组织显示出均的树皮纤维和正常的血管化.
- 恶性结节被鉴定为光素泄漏,表明血管透性异常.
- 在pCLE成像发现和组织学结果之间观察到显著的一致性.
结论:
- 基于探头的共聚焦激光内显微镜 (pCLE) 显示出作为手术内工具的前景.
- pCLE可以实时进行细胞分析,从而有可能改善外科手术指导.
- 该技术与传统组织学有很大一致性.
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