评估炎症标志物来区分多细胞血症 维拉与二次多细胞血症:新型诊断标志物的前景
Mohammad Navid Khaksari1,2, Kimia Oraei Sajjadi1,2, Fatemeh Arianmanesh1,2
1Department of Hematology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Annals of hematology
|January 14, 2026
概括
像SII,NLR和PLR这样的简单炎症标志物可以帮助诊断多细胞血病Vera (PV). 与二次多细胞血症患者相比,这些标志物在PV患者中升高,提供了具有成本效益的诊断替代方案.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 多细胞血症维拉 (PV) 是一种与慢性炎症和血栓形成相关的骨髓增殖性新生体.
- 作为PV的诊断标准之一的JAK2突变检测是昂贵的,而且不是所有人都能获得的.
- 炎症对PV病理生理学有很大的贡献.
研究的目的:
- 评估中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR) 和全身免疫炎症指数 (SII) 作为PV的潜在诊断标志物.
- 使用炎症标志物将PV患者与二次多细胞血症 (SP) 患者区分开来.
- 评估NLR,PLR和SII在区分PV和SP的诊断有效性.
主要方法:
- 一项回顾性研究涉及281名患有多细胞血症的患者 (110 PV,181 SP) 在Ghaem医院.
- 使用世界卫生组织标准确认PV诊断;非PV病例的SP诊断.
- 分析临床和实验室数据,包括NLR,PLR和SII,与接收器操作特征 (ROC) 分析.
主要成果:
- 与SP组相比,PV组的NLR,PLR和SII中位数显著高于SP组 (所有人p < 0.001).
- 通过ROC分析,NLR,PLR和SII在区分PV与SP患者方面表现出高效.
- 所有测试的标记物都显示了超过85%的灵敏度和特异性,曲线下面积> 0.9.9.
结论:
- 与二次多细胞血症患者相比,NLR,PLR和SII在多细胞血症患者中升高.
- 这些炎症标志物,特别是SII,显示出作为PV诊断的有价值,可访问的工具的希望.
- 这些发现表明,SII,NLR和PLR可以帮助区分PV和SP,可能减少对昂贵的JAK2突变测试的依赖.
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