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从古老的肠道微生物群中鉴定抗菌

Sizhe Chen^1,2, Yue Yuan³, Yun Wang^1,2

¹Microbiota I-Center (MagIC), Hong Kong SAR, China.

Nature communications

|January 14, 2026

概括

古老的便样本揭示了来自肠道细菌Segatella copri的强有力的抗菌 (AMP). 这些新型AMP显示出显著的抗微生物活性和伤口愈合特性,提供了新的治疗潜力.

科学领域:

微生物学微生物学
生物化学生物化学
生物信息学是一种生物信息学.

背景情况:

古老的便矿含有保存的微生物群.
抗微生物 (AMP) 对于先天免疫非常重要.
从古代微生物组中灭绝的AMP代表了新疗法的潜在来源.

研究的目的:

开发一种有效的工具 (AMPLiT) 用于在元基因组数据中选AMP.
来识别和表征从古代人类的coprolites的新型AMP.
研究来自Segatella copri的AMP的治疗潜力.

主要方法:

开发AMPLiT,这是一个轻量级工具,用于在元基因组数据集中识别AMP.
使用AMPLiT.使用七个古人类共聚物元基因组的计算分析.
40个候选AMP的合成和体外抗菌活性测试.
在体内评估类的抗菌和伤口愈合功效.

主要成果:

AMPLiT展示了高性能 (AUPRC 0.9486) 和高效的训练时间.
确定了160个AMP候选物,其中90%显示出体外抗菌活性.
三分之二的活性AMP来自Segatella copri.
从S. copri衍生出的AMP表现出强大的抗菌活性对病原体,低细胞毒性和有效的活体伤口愈合.

结论:

古代肠道微生物组是新型,高效AMP的宝贵来源.
塞加特拉·科普里 (Segatella copri) 是一个代表性不足的古老食人,产生强大的AMP,具有治疗潜力.
这些发现提供了关于S. copri在人类健康中的历史作用及其在现代人口中的衰退的见解.

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