瘤学中的肠道失调:免疫抵抗的一个危险因素
Andrew Allan Almonte1, Simon Thomas1, Valerio Iebba1,2
1Tumor Immunology and Cancer Immunotherapy, Université Paris-Saclay, Gustave Roussy, Inserm UMR1015, Villejuif, France.
Cell research
|January 14, 2026
概括
肠道微生物组显著影响癌症免疫治疗的有效性. 本综述探讨了微生物模式如何影响治疗反应,并讨论了基于微生物组的疗法,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 肠道微生物群影响对免疫检查点抑制剂 (ICI) 疗法的反应.
- 临床翻译受到不一致的失生症定义,不充分的生物标志物和不良的机制理解的限制.
研究的目的:
- 审查肠道微生物组成和功能对ICI疗效的影响.
- 讨论微生物组信息瘤学的计算模型和新兴治疗策略.
主要方法:
- 综合有关肠道微生物组和ICI疗效的当前知识.
- 对元基因组数据集的分析,以确定区分响应者与非响应者的微生物模式.
- 探索对免疫调节通路的抗生素效应.
主要成果:
- 肠道微生物的组成和功能是ICI反应的关键决定因素.
- 失生症扰乱了胆酸代谢,肠道透性和粘膜免疫调节.
- 像TOPOSCORE这样的机器学习模型提供了更具信息性的dysbiosis指数.
结论:
- 完善对肠道免疫相互作用的理解可以改善癌症治疗.
- 微生物组信息化的瘤学对免疫疗法耐药的患者有潜力.
- 新兴疗法,如饮食修改和便微生物群移植正在临床试验中.
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