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突变和ACE2诱导的Allosteric网络重新连接在delta和OmicronSARS-CoV-2尖端蛋白中

Mandira Dutta1, Gregory A Voth1

  • 1Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, IL 60637.

Biophysical journal
|January 15, 2026
PubMed
概括

这项研究揭示了Delta和Omicron等SARS-CoV-2变种如何使用它们的尖端蛋白来内部通信. 结合ACE2增强了这种沟通,影响了病毒感染力,并为新的抗病毒药物提供了标.

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