Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Typical Model Studies01:30

Typical Model Studies

619
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
619
Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

674
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
674
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

288
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
288
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

245
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
245
Modeling and Similitude01:12

Modeling and Similitude

613
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
613
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

242
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
242

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

EA1-linked Kv1.1 dysfunction enhances susceptibility to cerebellar spreading depression and a transient cerebellar refractory state.

Biochimica et biophysica acta. Molecular basis of disease·2026
Same author

Astrocyte-derived miR-124 impairs glioma cell volume regulation and migration by reducing Ca<sup>2+</sup>-dependent IK channel expression and activation.

Cellular and molecular life sciences : CMLS·2026
Same author

Celebrating 50 Years of Single-Channel Recording with the Patch Clamp.

The Journal of membrane biology·2025
Same author

Piezo1 is an essential player in volume regulation of human glioblastoma cells.

The Journal of physiology·2025
Same author

Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches.

Frontiers in cellular neuroscience·2025
Same author

The crucial decade that ion channels were proven to exist : The vision of Bertil Hille and Clay Armstrong and how it came through.

Pflugers Archiv : European journal of physiology·2025
Same journal

Heterogeneous binding of SARS-CoV2 fusion peptide on complex cellular membranes enhances its fusogenicity.

Biophysical journal·2026
Same journal

Tau protein differentially affects Piezo1 and Kir2.1 channels in brain capillary endothelial cells.

Biophysical journal·2026
Same journal

Emergent Intercellular Junction Stability during Cyclic Tissue Loading.

Biophysical journal·2026
Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026
Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
查看所有相关文章

相关实验视频

Updated: Jan 16, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.6K

一种基于线性编程的方法,用于构建实验驱动的漏模型.

Luigi Catacuzzeno1, Maurizio G Cavaliere1, Antonio Michelucci1

  • 1Department of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy.

Biophysical journal
|January 15, 2026
PubMed
概括
此摘要是机器生成的。

本研究介绍了一种线性编程 (LP) 方法,用于估计漏 (P-L) 模型中难以找到的参数. 这种方法可以进行精确的细胞建模,以更好地了解离子运输和细胞生理学.

关键词:
细胞的离子恒温.离子输送器 离子输送器线性编程是一种线性编程.调节体积的调节器

更多相关视频

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators
08:59

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators

Published on: June 13, 2022

2.9K
A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps
07:34

A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps

Published on: August 5, 2015

9.8K

相关实验视频

Last Updated: Jan 16, 2026

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump
09:04

A Modeling and Simulation Method for Preliminary Design of an Electro-Variable Displacement Pump

Published on: June 1, 2022

3.6K
Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators
08:59

Modeling and Experimental Analysis of the Single-Shaft Coaxial Motor-Pump Assembly in Electrohydrostatic Actuators

Published on: June 13, 2022

2.9K
A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps
07:34

A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps

Published on: August 5, 2015

9.8K

科学领域:

  • 细胞生理学 细胞生理学
  • 计算生物学 计算生物学
  • 生物物理学的生物物理.

背景情况:

  • -泄漏 (P-L) 模型对于了解离子度,体积和膜潜力的细胞调节至关重要.
  • 对特定细胞类型的P-L模型进行参数化是很困难的,因为这些参数在实验上是无法获得的.

研究的目的:

  • 开发一种基于线性编程 (LP) 的新型反向方法,用于P-L模型中估计不可访问的参数.
  • 为在不同细胞类型中提供P-L模型参数化的通用化策略.

主要方法:

  • 使用线性编程 (LP) 方法在 P-L 模型框架内估计未知参数.
  • 在P-L模型的微分方程中应用了稳定状态条件,将时间导数设置为零.
  • 使用实验测量的离子度,膜电压和细胞体积作为约束来解决模型参数.

主要成果:

  • 通过基于LP的方法成功构建了U87-MG质母细胞瘤细胞系的P-L模型.
  • 开发的P-L模型在细胞外Na+变化和抑制离子导电的条件下准确预测了细胞体积变化.
  • 证明了该方法在系统探索参数范围和汇聚到独特解决方案中的有效性.

结论:

  • 基于LP的反向方法为参数化复杂的PL模型提供了一个有效的策略.
  • 这种方法促进了对离子运输机制和细胞动态的更深入的定量理解.
  • 提供了一个用户友好的计算机应用程序来实现这种可通用的PL模型参数化技术.