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婴儿早期的母亲和婴儿微生物群:随机对照试验的纵向发现
Jinyue Yu1,2, Yan Zhang3, Jonathan C K Wells1
1Department of Population, Policy & Practice, UCL Great Ormond Street Institute of Child Health, Childhood Nutrition Research Group, London, UK.
Journal of pediatric gastroenterology and nutrition
|January 15, 2026
概括
早期婴儿的肠道和母乳微生物在产后的前8周内发生变化,而母亲的肠道微生物保持稳定. 减少母亲的压力可能会影响母乳的微生物组成.
科学领域:
- 微生物组研究的研究.
- 母婴健康 孕产妇和婴儿健康
- 产后恢复 产后恢复
背景情况:
- 早期的微生物殖民对婴儿健康至关重要.
- 母亲的压力会影响母亲的微生物组和潜在的婴儿发育.
- 产后监禁做法可能会影响母亲和婴儿的微生物暴露.
研究的目的:
- 描述母亲肠道,母乳和婴儿肠道的早期产后微生物发育.
- 探索母亲压力对这些微生物群落的影响.
- 评估母亲放松干预对微生物组的影响.
主要方法:
- 一个随机对照试验的二次分析,涉及母亲和纯母乳养的婴儿.
- 从产后1到8周收集母亲便,母乳和婴儿便样本.
- 16S rRNA基因扩增序列测序用于分析微生物群的多样性和组成.
主要成果:
- 在所有样本类型中,微生物群多样性保持稳定.
- 母乳微生物群的组成暂时发生变化,特别是在对照组.
- 随着时间的推移,婴儿肠道微生物群显示Bifidobacterium增加,Staphylococcus和Enterobacteriaceae减少.
- 只有在干预组中观察到母乳葡萄球菌的减少.
结论:
- 母乳和婴儿肠道微生物组成在产后的前8周发生显著变化.
- 在此期间,母亲的肠道微生物群组成保持稳定.
- 减少母亲压力的干预措施显示出调节母乳微生物群的潜力.
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