在下痢症中存在与物质相关问题的风险
Kayoko Isomura1, Susanna Österman1, Erik Hedman-Lagerlöf2
1Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Psychological medicine
|January 15, 2026
概括
患有下痢症 (健康焦虑障碍) 的人面临与物质相关问题的风险明显更高. 早期识别和意识到物质滥用对于改善这一群体的长期结果至关重要.
科学领域:
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 抑郁症或健康焦虑障碍与死亡率的增加有关,通常是由于可预防的原因.
- 药物滥用和缺陷性肌肉症之间的联系还不太清楚.
- 这项研究调查了被诊断患有下痢症的个体中与物质有关的问题的风险.
研究的目的:
- 评估下痢症诊断与患上与物质相关问题的风险之间的关联.
- 为了检查这种关联是否在控制社会人口统计和精神病史等混因素后仍然存在.
主要方法:
- 一个瑞典基于登记的匹配队列研究.
- 包括4129名被诊断患有下痢症的个人和41290名匹配的对照.
- 使用考克斯的比例危险模型来估计各种与物质有关的问题的风险,并对共变量进行调整.
主要成果:
- 患有下痢症的人患有与物质有关的问题的风险增加了2.55倍 (HR,2.55;95% CI,2.30-2.84).
- 即使在调整为精神病相关疾病后,这种关联仍然很重要.
- 在初级保健中诊断的下症中也观察到较高的风险 (HR, 1.61; 95% CI, 1.39-1.86).
结论:
- 缺口症明显与与物质相关问题的风险增加有关.
- 对滥用药物的临床意识和认知对于减轻健康焦虑患者的不良结果至关重要.
- 对这种关联背后的机制进行进一步的研究是有必要的.
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