偏头痛,并发症和严重孕产妇和新生儿发病率或死亡率的风险:基于人口的队列研究
Carmela Melina Albanese1,2, Susan J Bondy1,2, Christine Lay3
1Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
American journal of epidemiology
|January 15, 2026
概括
偏头痛和其他慢性疾病显著增加严重的母亲和新生儿并发症的风险. 患有这两种疾病的妇女需要加强孕前和产周护理,以改善结果.
科学领域:
- 产科和妇科 产科和妇科
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 偏头痛是一种神经系统疾病,与不良周产期结局有关.
- 偏头痛和并发症对母亲和新生儿风险的综合影响需要研究.
研究的目的:
- 检查偏头痛和并发症对严重孕产妇发病率/死亡率 (SMM-M) 和严重新生儿发病率/死亡率 (SNM-M) 的单独和联合影响.
- 评估偏头痛和并发症之间对这些不良结果的附加相互作用.
主要方法:
- 在加拿大安大略省 (2007-2022) 基于人口的2,643,335例怀孕队列研究.
- 四组的比较:偏头痛与并发症,偏头痛单独,并发症单独,没有.
- 修改Poisson回归分析用于计算调整后风险比率 (aRR) 和因相互作用而导致的归因比例 (aAP).
主要成果:
- 对SMM-M (aRR 1.60) 和SNM-M (aRR 1.43) 的最高风险是在偏头痛和并发症患者中观察到的.
- 单独患有其他慢性病的人也存在高风险 (SMM-M aRR 1.34;SNM-M aRR 1.30).
- 偏头痛单独显示了风险的适度增加 (SMM-M aRR 1.13; SNM-M aRR 1.07),具有很小的附加相互作用效应.
结论:
- 偏头痛与其他慢性疾病相结合,构成严重围产期并发症的最大风险.
- 虽然协同效应很小,但建议针对偏头痛和并发症患者提供有针对性的预孕和围产期支持.
- 这些干预措施可能有助于减轻增加的孕产妇和新生儿发病/死亡风险.
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