超越埃索诺菲尔:在疑似埃索诺菲尔食道炎的重塑和炎症的蛋白质剖析
Adi Eindor-Abarbanel1,2, Nimrod Moss-Ophir1, Netanel Agajany1
1Pediatric Gastroenterology, Hepatology and Nutrition Division, Shamir Medical Center, Zerifin, Israel.
Journal of pediatric gastroenterology and nutrition
|January 15, 2026
概括
这项研究确定了性食道炎 (EoE) 的新蛋白质生物标志物,包括与炎症和组织变化相关的CCL26. 这些发现可能会改善EoE诊断和治疗策略.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 生性食道炎 (EoE) 诊断依赖于生细胞计数,但其他组织学特征如基底细胞增生 (BCH) 被忽视.
- 目前对EoE的生物标志物主要集中在eosinophilia上,忽视了可能在治疗后持续存在的其他病理方面.
研究的目的:
- 使用炎症生物标志物概况,区分EOE与非EOE.
- 在EoE中识别与基底细胞增生 (BCH) 相关的生物标志物.
- 探索生物标志物,质子抑制剂 (PPI) 反应和EoE患者的食物影响之间的关系.
主要方法:
- 一项前性病例控制研究,涉及86名年龄在6-65岁的患者进行内镜检查.
- 使用Olink® Explore 384炎症面板进行血清蛋白质组分析.
- 对EoE与非EoE组之间的生物标志物表达的统计比较,以及BCH与非BCH组之间的BCH表达,调整为临床因素.
主要成果:
- 在EoE中,CCL26被显著上调,并且与BCH相关,即使在调整以色素细胞计数后也是如此.
- ITGA11和TNFRSF11A显示了与BCH的名义关联,独立于氨基酸水平.
- COL9A1与PPI反应有关,而 Kostatin M (OSM) 和TGF-α与食物影响有关.
结论:
- 高通量蛋白质组学确定了EoE的独特生物标志物签名,CCL26是炎症和重塑的关键标志物.
- COL9A1可能表明与GERD相关的炎症,并预测PPI反应.
- 这些发现表明了EoE的双通道模型,并突出了生物标志物导向诊断和治疗的潜力.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...


