在阿尔茨海默病中,大脑外围蛋白质组交叉连接,有或没有糖尿病
Anat Yaskolka Meir1, Xingyan Wang1, Shinya Tasaki2
1Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA.
这项研究通过分析大脑,肌肉和血清来探索糖尿病 (DM) 和阿尔茨海默病 (AD) 之间的联系. 肌肉SARS2-S126和血清AHSG-S346/IGFBP2-S142显示出作为AD生物标志物的潜力,特别是在DM患者中.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 蛋白质组学是指蛋白质组学.
背景情况:
- 糖尿病 (DM) 是已知的阿尔茨海默氏症 (AD) 痴呆症的风险因素.
- 外围生物过程与AD中心病理之间的机制联系,特别是在DM的背景下,需要进一步阐明.
研究的目的:
- 为了研究中枢 (大脑) 和外围 (肌肉,血清) 组织之间的蛋白质组交叉声在患有和没有病态AD和DM的个体中.
- 为了识别AD的潜在外围生物标志物,特别是在糖尿病的存在下.
主要方法:
- 基于双重质量标签的蛋白质组概况分析是在死后的前额叶皮质,状肌肉和死前血清样本上进行的.
- 从191名脑和肌肉样本和96名血清样本中获取了样本,按AD病理和DM状态分层.
主要成果:
- 观察到大脑和肌肉脂蛋白之间存在显著的相关性,大脑和血清脂蛋白之间存在较弱的相关性.
- 肌肉血-tRNA合成酶2 (SARS2) -S126与病理性AD有显著的关联.
- 血清α-2-HS-糖蛋白 (AHSG) -S346和胰岛素样生长因子结合蛋白2 (IGFBP2) -S142在糖尿病组中与AD有边际关联.
结论:
- 阐明中心和外围蛋白质体之间的交叉是发现新型AD生物标志物的关键.
- 可访问的外围生物样本,如血清和肌肉,有望用于识别与AD病理学相关的生物标志物,特别是在糖尿病患者中.
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