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Updated: Jan 16, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

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基于6−(Het) aryl-7-deazapurine Ribonucleoside 5'−O‐Bisphosphonates的强有力的竞争性抑制剂Ecto-5'-核酶 (CD73) 的作用

Ugnė Šinkevičiu̅tė1,2, Magdalena Šímová1, Radek Staník1,2

  • 1Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam. 2, Prague 6 CZ-16610, Czech Republic.

ACS pharmacology & translational science
|January 15, 2026
PubMed
概括

研究人员开发了新的7-deazapurine ribonucleoside bisphosphonates,作为癌症免疫疗法的强效CD73抑制剂. 这些化合物有效地阻断了腺的产生,增强了T细胞的活性,并显示出有利的药物特性.

关键词:
这是一种CD73抑制剂.癌症免疫疗法免疫疗法核酸双酸盐是一种核酸双酸盐.核酸中的核酸.皮罗罗皮里米丁酸盐是什么

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NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases10:24

NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases

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