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Updated: Jan 16, 2026

Determination of High-affinity Antibody-antigen Binding Kinetics Using Four Biosensor Platforms
15:27

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Published on: April 17, 2017

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预测人类单克隆抗体的药理动力学:使用生理学基础的药理动力学 (PBPK) 建模识别参考新生儿Fc受体 (FcRn) 结合亲缘关系

Salih Benamara1,2, Erik Sjögren3, Florence Gattacceca2

  • 1Translational Medicine Unit, Quantitative Pharmacology, Development Pharmacometrics, Sanofi, Vitry-sur-Seine 94400, France.

ACS pharmacology & translational science
|January 15, 2026
PubMed
概括

预测单克隆抗体 (mAb) 药理动力学 (PK) 是一个挑战. 这项研究开发了一种使用FcRn受体的通用解离常数 (KdFcRn) 值的标准化方法,改善了早期临床试验中的PK预测.

关键词:
这就是KdFcRnnn.PBPKK PBPK 的意思是什么意思人类中的第一人.这是一种单克隆抗体.

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