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肠道菌群与急性辐射肠炎在患有晚期宫癌且同时接受化学放射治疗的患者之间的关系
Ziye Zheng1, Siqi Sun2, Jiawei Zhu1
1Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Advances in radiation oncology
|January 15, 2026
概括
宫癌患者的急性辐射肠炎腹与肠道细菌的变化有关. 严重的腹与微生物多样性的减少和炎症细菌的增加有关,这表明肠道失调有作用.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 急性辐射肠炎 (RE),特别是腹,对于接受同时化学放射治疗 (CCRT) 的局部晚期宫癌 (LACC) 患者来说是一个显著的并发症.
- 了解CCRT期间肠道菌群的动态变化对于管理RE相关的腹至关重要.
研究的目的:
- 在接受CCRT的LACC患者中调查动态肠道菌群变化与辐射肠炎相关腹的严重程度之间的关系.
- 为了确定与轻度与严重腹相关的特定微生物变化.
主要方法:
- 一项前性观察队列研究包括83名接受CCRT的LACC患者.
- 在基线,第4周和第8周使用16SrRNA测序分析便样本.
- 评估了微生物多样性,分类学组成,功能途径和临床相关性.
主要成果:
- 腹的严重程度在4-5周之间达到峰值,随后下降.
- 严重的腹病例在第4周显著减少了α多样性,Firmicutes/Bacteroidetes比率发生了变化.
- 在严重腹组中,特定的种群如*Bacteroides*和*Lachnoclostridium*被丰富,而*Ruminococcaceae*被减少.
- 与氨基/核酸糖代谢相关的代谢途径受到上调,不和脂肪酸生物合成在严重组下调.
结论:
- 在宫癌患者中,与急性辐射肠炎相关的腹与肠道失生症有关.
- 严重的腹与减少的微生物α多样性,较低的Firmicutes/Bacteroidetes比率以及促炎性种群的丰富相关.
- 这些发现凸显了向肠道微生物群的潜力,以减轻与RE相关的腹.
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