亚临床甲状腺功能低下症作为冠状动脉旁路移植的风险
Ricardo Mendes Martins1,2, Felipe José M Pittella2, Beatriz C de Oliveira1
1Department of Internal Medicine, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil, uff.br.
Cardiovascular therapeutics
|January 15, 2026
概括
亚临床甲状腺功能低下症 (SH) 增加了主要不良心血管事件 (MACE) 和术后并发症的风险,包括中风和心房动,在接受冠状动脉旁路移植 (CABG) 的患者中. 乙甲状腺患者的不良结果较少.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 心血管外科心血管外科
背景情况:
- 甲状腺功能低下症和心血管疾病 (CVD) 之间的确立联系是已知的.
- 关于亚临床甲状腺功能低下症 (SH) 和其对主要不良心血管事件 (MACE) 和冠状动脉旁路移植 (CABG) 后术后并发症的影响的数据有限.
研究的目的:
- 为了研究亚临床甲状腺功能低下症 (SH) 与接受CABG的患者中MACE和术后并发症的风险之间的联系.
- 为了比较SH患者和CABG后的euthyroid患者之间的结果.
主要方法:
- 分析了2010年至2019年间接受CABG的863名患者的队列.
- 主要结局包括MACE (全因死亡,心血管死亡,中风,急性心肌梗塞,新血管化) 和术后并发症 (心房动,多叶膜溢出,心周溢出,感染,中炎).
主要成果:
- 在SH患者中,MACE的发生率 (20.3%对8.2%) 和中风的发生率 (10.2%对3.0%) 与非甲状腺患者相比显著更高.
- 术后并发症在SH组中更为频繁,包括心房动 (18.6%与9.7%相比),胸腔溢出 (52.6%与19.2%相比),心周溢出 (20.3%与7.8%相比) 和感染 (28.8%与16.9%相比).
- 在所有死因,心血管死亡,急性心肌梗塞,新血管化或中炎方面没有发现显著差异.
结论:
- 亚临床甲状腺功能低下症与MACE的风险增加以及CABG后的几个术后并发症有关.
- 这些发现强调了考虑SH作为心血管手术患者的风险因素的重要性.
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