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Updated: Jul 17, 2026

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基于thalidomide的PROTAC的综合计算屏幕和验证,针对SARS-CoV-2主要蛋白酶

Li-Na Guo1, Yu-Hua Li1, Rou-Yu Zhu2

  • 1NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies Shanghai 200237 China guoln90@126.com li_yuhua@163.com diaohua@sibpt.cn.

RSC medicinal chemistry
|January 15, 2026
PubMed
概括

新的蛋白质分解向化体 (PROTACs) 有效地降低了SARS-CoV-2主要蛋白酶 (Mpro). 这些PROTAC提供了一个有前途的催化降解策略,用于对抗药物耐药的病毒标.

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Inhibitors of Virion Maturation and Assembly01:19

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...