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在过去40年中,变化的微生物学和PD相关炎的结果

Leonie Kraft¹, Julia Oppold², Daniel Kitterer³

¹Department of General Internal Medicine and Nephrology, Robert Bosch Hospital Stuttgart, Stuttgart, Germany.

Clinical kidney journal

|January 15, 2026

概括

腹膜透析腹膜炎的趋势显示,在40多年中,格兰氏阴性感染的增加和凝结酶阴性葡萄球菌的减少. 多微生物和阴性腹膜炎与更糟糕的结果有关,需要改善监测和抗生素管理.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病
微生物学微生物学

背景情况:

腹膜透析 (PD) 相关的腹膜炎是一种严重的并发症,影响患者的治疗结果和透析方式的存活率.
了解致病原体和抗生素敏感性的时间趋势对于有效管理至关重要.

研究的目的:

评估四十年 (1979-2024) 的PD相关周周炎病原体分布和抗生素敏感性的变化.
评估最近十年的临床结果,包括治愈率,导管切除和过渡到血液透析.

主要方法:

从1979年至2024年期间接受治疗的PD患者的832种腹膜炎培养物的回顾性分析.
将研究期划分为四个不同的时间间隔,以便进行纵向比较.
在2015-2024年期间评估临床反应和结果.

主要成果:

格拉姆阳性细菌是最常见的原因 (56%),其次是格拉姆阴性细菌 (30%).
在最近一段时间 (2015-2024年) 中,格拉姆阴性腹膜炎显著增加,而凝结酶阴性葡萄球菌减少 (P=.0446).
近期的整体治愈率为63%;多微生物和グラム阴性腹膜炎与更高的导管切除率和过渡到血液透析有关.

结论:

在过去的四十年中,PD相关的腹膜炎的微生物格局发生了显著的时间变化.
多微生物和格拉姆阴性腹膜炎与较差的临床结果有关,这凸显了需要警的微生物监测的需要.
优化PD护理需要持续的抗生素管理和适应不断变化的病原体趋势.

关键词:

临床反应的临床反应.长期观察长期观察微生物学的模式腹膜透析是指腹膜透析.膜炎是一种膜炎.

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