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在艾滋病毒感染者持续抗逆转录病毒治疗期间,纵向T细胞表型动力学

Christophe Vanpouille¹, Alan Wells², Victor DeGruttola³

¹Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Open forum infectious diseases

|January 15, 2026

概括

长期抗逆转录病毒疗法 (ART) 部分恢复了HIV-1患者的免疫功能,减少了T细胞活化,但没有消除T细胞耗尽或细胞毒性标志物.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
艾滋病毒/艾滋病研究研究

背景情况:

抗逆转录病毒治疗 (ART) 对于抑制HIV-1复制和改善免疫功能至关重要.
尽管有ART,持续的免疫异常仍然是管理HIV-1感染的重大挑战.

研究的目的:

研究ART对病毒抑制个体T细胞表型的长期影响.
评估免疫激活,循环,疲劳,细胞毒性和调节标志物的变化.
探索T细胞表型,性别和HIV储存库特征之间的关联.

主要方法:

纵向多参数流细胞测量对79名艾滋病毒-1感染者的外周血液单核细胞进行了测量.
分析了T细胞数量和关键激活,循环,疲劳,细胞毒性和调控标记物的表达.
数据分析了平均6年的ART,检查了与性别的关联和HIV储存量措施的数据.

主要成果:

CD4+ T细胞数量增加,CD8+ T细胞数量减少,随着时间的推移,CD4/CD8比率得到改善.
免疫激活和循环标记物下降,而CD4+T细胞耗尽标记物 (TIGIT/PD-1) 则下降.
CD8+ T细胞耗尽标记仍然高,细胞毒性标记 (CD107a) 在效应记忆子集中持续高.

结论:

长期的ART导致部分免疫正常化,包括T细胞活化减少和CD4+T细胞耗尽.
持续的CD8+T细胞耗尽标志物和细胞毒性表明正在进行的抗原刺激,可能来自HIV储存器或共感染.
免疫正常化还不完全,这凸显了需要策略来解决治疗HIV-1的残留免疫功能障碍.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒一个T细胞细胞.流动细胞计量是流动细胞计量的方法.长期的ART治疗方法

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