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相关概念视频

Thermoregulation01:26

Thermoregulation

2.3K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Body Temperature01:25

Body Temperature

4.0K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
4.0K
Body Temperature01:07

Body Temperature

1.3K
Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C...
1.3K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

4.3K
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.3K
Thermosensation01:43

Thermosensation

33.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.7K
What is Homeostasis?01:16

What is Homeostasis?

52.3K
Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
52.3K

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相关实验视频

Updated: Jan 16, 2026

Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions
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Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

Published on: March 9, 2021

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人类热调节的基因网络和知识库.

E V Ignatieva1, P S Demenkov1, A G Bogomolov1

  • 1Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Vavilovskii zhurnal genetiki i selektsii
|January 15, 2026
PubMed
概括

这项研究重建了人类的温度调节基因网络,确定了参与维持体温的关键基因,蛋白质和微RNA. 这些发现突出了这些关键的温度调节元件的古代进化起源.

关键词:
寒冷的冷冷的冷冷的冷冷的冷冷的我们的数据库数据库数据库数据库.进化 演化 演化 演化 演化 演化 演化 演化基因 年龄 基因 年龄基因网络 基因网络热量 热量 热量 热量 热量这是一个微型RNA.植物学地图 (phylostratigraphy) 是一种地图.

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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Measuring Skeletal Muscle Thermogenesis in Mice and Rats
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Measuring Skeletal Muscle Thermogenesis in Mice and Rats

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相关实验视频

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Field-Based Thermal Physiology Assay: Cold Shock Recovery under Ambient Conditions

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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
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Measuring Skeletal Muscle Thermogenesis in Mice and Rats
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Measuring Skeletal Muscle Thermogenesis in Mice and Rats

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科学领域:

  • 系统生物学 系统生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 热调节对于热血动物至关重要,涉及多个生理系统.
  • 了解基因网络对于研究复杂的生物系统至关重要.

研究的目的:

  • 以计算方式重建人类温度调节基因网络.
  • 创建Termo_Reg_Human 1.0知识库,详细介绍这个网络.
  • 确定调节人类温度调节的关键基因,蛋白质和微RNA.

主要方法:

  • 利用ANDSystem软件从科学文献和数据库中自动提取知识.
  • 用机器学习和人工智能来重建基因网络.
  • 应用ANDVisio来根据功能互动对网络组件进行优先排序.

主要成果:

  • 开发了Termo_Reg_Human 1.0知识库,其中包括469个基因,473个蛋白质和265个微RNA.
  • 确定了关键的调控元素,包括UCP1,VEGFA,PPARG,DDIT3基因;STAT3,JUN,VEGFA,TLR4,TNFA蛋白质;以及hsa-mir-335,hsa-mir-26b微RNAs.
  • 发现了具有早期进化起源 (单细胞,脊椎动物阶段) 的基因的丰富.

结论:

  • 重建后的网络为人类温度调节研究提供了全面的资源.
  • 确定了关键的基因,蛋白质和microRNAs对于温度调节功能至关重要.
  • 这项研究强调了人类温度调节机制的深刻进化根源.