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慢性质子抑制剂使用中的胰腺功能:跨截面研究的发现
Leo Francis Chalissery1, Madhavi Eerike2, Lisha Francis Chalissery3
1Senior Resident, Department of Pharmacology, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India, PIN-508126.
Maedica
|January 15, 2026
概括
长期使用质子抑制剂 (PPI) 与胰腺功能障碍没有明确的联系. 然而,HbA1c升高的高患病率表明需要进一步调查的潜在关联.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 质子抑制剂 (PPI) 经常用于与酸有关的胃肠道疾病.
- 新兴研究表明,长时间使用PPI和胰腺功能障碍之间可能存在联系,但证据是相互矛盾的.
- 这项研究研究了长期接受PPI治疗的个体的胰腺功能标志物.
研究的目的:
- 在接受慢性质子抑制剂治疗的患者中评估胰腺功能.
- 探索PPI使用与胰腺健康标志物之间的潜在关联.
- 澄清长期PPI治疗与胰腺功能障碍之间的关系.
主要方法:
- 一项横截面研究包括97名成人门诊患者使用PPI至少8周 (≥3剂/周).
- 排除标准包括糖尿病或同时使用影响葡萄糖的药物.
- 血液测试测量了C-,氨酶,糖化血红蛋白 (HbA1c) 和随机血糖 (RBS);统计分析确定了相关性.
主要成果:
- 研究人口的平均年龄为51.2岁,女性为62.9%;潘托普拉是最常见的PPI (76.3%).
- 在10.3%的参与者中发现异常的C-水平,表明胰腺功能障碍.
- 增加的HbA1c水平很普遍 (48.5%),但胰腺功能标志物与年龄,性别,PPI类型或持续时间之间没有发现显著的关联.
结论:
- 这项研究没有确定慢性PPI使用与胰腺功能障碍之间的确切联系.
- 长期使用PPI的人群中HbA1c升高的高发病率要求进一步调查潜在的关联.
- 需要进一步的研究来阐明PPI和胰腺健康之间的复杂关系.
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