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Updated: Jan 16, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Published on: December 9, 2016

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QKI失调诱导了T细胞急性淋巴细胞白血病的广泛拼接变化

Bruno Palhais1, Nitesh D Sharma2, Igor Fijalkowski3

  • 1Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium; Normal and Malignant Hematopoiesis Lab, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium; Leukemia Therapy Resistance Unit, Department of Biomolecular Medicine, Ghent University, Ghent. bruno.palhais@ugent.be.

Haematologica
|January 15, 2026
PubMed
概括

震 (QKI) 是T细胞急性淋巴细胞白血病 (T-ALL) 的瘤抑制剂. 减少QKI表达与生存率差相关,恢复QKI可以抑制白血病的进展.

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