在患有非功能性下垂体腺瘤的患者中,转录因子和荷尔蒙免疫抑制的性别和年龄差异
Amara Emeh1, Erica Gillespie1, David J Cote1
1Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Operative neurosurgery (Hagerstown, Md.)
|January 15, 2026
概括
性别和年龄显著影响非功能性垂体腺瘤 (NFPA) 基于转录因子 (TF) 和激素免疫染的分类. 这些人口因素可能在NFPA的发展和进展中发挥作用.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 非功能性垂体腺瘤 (NFPA) 传统上是通过激素免疫染来分类的.
- 2017年世界卫生组织的指导方针引入了基于T-PIT,PIT-1和SF-1等转录因子 (TF) 的分类.
研究的目的:
- 使用TF标准调查生物性别,年龄和NFPA免疫组织化学 (IHC) 模式之间的关联.
- 评估人口因素与NFPA亚型的相关性.
主要方法:
- 从2012年到2023年在一个机构进行NFPA切除数据的回顾性审查.
- 患者按生物学性别和年龄组进行分类.
- 使用不变的统计数据来分析人口统计和NFPA IHC之间的关联.
主要成果:
- 男人表现出明显的IHC模式,T-PIT和ACTH阳性较少,SF-1,FSH,LH,TSH和α子单元阳性较多.
- 老年女性更有可能患有SF-1,FSH和α子单元阳性NFPA.
- 年长的男性增加了FSH和α子单元的阳性,并降低了ACTH阳性.
结论:
- 生物性别和年龄是与NFPA免疫染模式和TF血统亚型相关的显著人口统计因素.
- 受到年龄和性别影响的内分泌因素可能会导致NFPA瘤发生或进展.
相关概念视频
Major Hormones and Their Functions
1.7K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.7K
Hormones of the Pituitary Gland
9.4K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
9.4K
Signs of Puberty
1.4K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
1.4K


