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杂交螺杆菌体中的转录基因可塑性可能有助于它们的动物感染潜力

Nelia Luviano Aparicio^1,2, Eglantine Mathieu-Bégné^1,3, Julien Kincaid-Smith⁴

¹IHPE, University Perpignan Via Domitia, CNRS, IFREMER, University Montpellier , Perpignan66860, France.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

|January 15, 2026

概括

杂交istosomes表现出了显著的适应性,增加了动物感染风险,并复杂化了istosomiasis控制. 转录基因可塑性允许这些寄生虫在各种宿主中壮成长,这给疾病管理带来了挑战.

科学领域:

寄生虫学的寄生虫学
基因组学就是基因组学.
进化生物学进化生物学

背景情况:

Schistosoma haematobium和Schistosoma bovis之间的杂交会导致人类和动物的复杂感染.
杆菌感染多种反动物,扩大跨物种传播和动物感染潜力.
了解寄生虫的适应性对于控制杆菌病至关重要.

研究的目的:

调查转录基因可塑性作为混合分裂体适应不同宿主的机制.
为了比较进化杂交物中的基因表达与父母S. bovis. 的基因表达.
分析S. bovis. 宿主依赖的基因表达变化.

主要方法:

对羊群内进化的S. haematobium × S. bovis杂交物的转录组分析.
在子和绵羊宿主中S. bovis基因表达的比较.
差异基因表达分析和生物通路的丰富.

主要成果:

内向性与杂交动物中的366个不同表达的基因有关,与绵羊中的S. bovis相比.
S. bovis表现出显著的宿主依赖转录基因变化,其中30%的基因在子和绵羊感染之间发生了变化.
共享的丰富途径包括核mRNA代谢和线粒体组织,表明增强的可塑性和代谢适应性.

结论:

转录组的可塑性增强了S. bovis和杂交石体的适应性.
增加的适应性引发了对扩大传输能力和动物感染潜力的担忧.
寄生虫的可塑性复杂化了杆菌病的控制策略和干预工作.

关键词:

史基斯托索马杂交的杂交物异质化异质化是什么意思主机变更的主机变更转录的可塑性转录的可塑性动物传染病风险动物传染病风险

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