淋巴结转移模式在复发性和异侧性第二次原发性口腔状细胞癌中
Yijing Cai1,2,3, Maged Ali Al-Aroomi1,2,3, Jie Chen1,2,3
1Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Clinical oral investigations
|January 15, 2026
概括
再发性口腔状细胞癌 (OSCC) 和第二次原发性瘤 (SPT) 的淋巴结转移率较高,特别是在特定的部水平. 这种模式表明,患有复发性OSCC或SPT的患者的预后较差.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症转移研究 癌症转移研究
背景情况:
- 口腔状细胞癌 (OSCC) 复发和第二次原发性瘤 (SPT) 存在独特的临床挑战.
- 了解复发性OSCC和SPT中的转移模式对于有效管理至关重要.
研究的目的:
- 在患有复发性OSCC或ipsilateral SPT的患者中分析淋巴结转移模式.
- 在这些患者群体中确定与转移相关的风险因素.
- 为治疗复发性和二次性口腔癌的临床诊断和治疗策略提供信息.
主要方法:
- 复发性OSCC或ipsilateralSPT患者进行激进手术的回顾性分析 (2017年1月至2023年3月).
- 收集和审查全面的临床和病理学数据.
- 多变量逻辑回归用于识别淋巴结转移的危险因素.
主要成果:
- 与初级OSCC (22.9%) 相比,复发性/SPT的淋巴结转移率 (42.2%) 显著更高.
- 转移模式有所不同:主要的OSCC偏爱I-III级别,而复发性/SPT通常涉及ipsilateral级别V和逆向级别I.
- 瘤差异化和T2阶段是淋巴结转移的重要风险因素,无论是初级和复发/SPT设置.
结论:
- 复发性和两侧性SPT对淋巴结转移的倾向增加,特别是在特定的部区域 (两侧水平V,两侧水平I).
- 这些明显的转移模式在复发/SPT中与预后明显差相关.
- 研究结果强调需要针对复发性或二次性口腔癌患者量身定制的监测和管理方法.
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