在B细胞淋巴瘤中的双特异抗体之后的感染
Dong Hyun Kim1, Naryllae Lee2, Youngil Koh1
1Seoul National University Hospital, Seoul, Korea, Republic of.
Blood advances
|January 15, 2026
概括
对B细胞淋巴瘤的双特异性抗体 (BsAbs) 导致严重的感染,像CMV这样的病毒感染很常见. 中性贫和低型球蛋白血症增加了感染风险,需要量身定制的支持性护理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 双特异性抗体 (BsAbs) 为B细胞淋巴瘤提供了新的治疗方法.
- 感染是已知的并发症,但其频谱和风险因素需要进一步描述.
研究的目的:
- 评估B细胞淋巴瘤患者感染的发病率,特征和风险因素,这些患者接受CD3×CD20 BsAbs.Abs.治疗.
- 提供感染发病和类型的时间分析.
主要方法:
- 从2016年到2024年对122名接受CD3×CD20 BsAbs治疗的患者进行了回顾性队列研究.
- 分析传染病发作,发病时间,致病因子和危险因素,包括中性质衰竭和低球蛋白血症.
主要成果:
- 在74名患者 (60.7%) 中发生了143次感染发作,其中61.5%为≥3.3级.
- 病毒感染是最常见的 (62.1%),特别是SARS-CoV-2和细胞巨型病毒 (CMV).
- 中性贫和低聚环球血是感染的独立风险因素;低聚环球血预测严重的感染.
结论:
- 在接受BsAbs.治疗的B细胞淋巴瘤患者中,感染频繁且可能严重.
- 转基因病毒的重新激活是一种未被认可的并发症.
- 适应风险的策略和增强的支持性护理对于管理这一群体感染至关重要.
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