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Updated: Jun 29, 2026

Targeted DNA Methylation Analysis by Next-generation Sequencing
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Published on: February 24, 2015

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机器学习揭示了细菌中的SaCas9-PAM相互作用的序列和甲基化决定因素

Dalton T Ham1, Tyler S Browne1, Claire Q Zhang1

  • 1Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London ON N6A 5C1, Canada.

Nucleic acids research
|January 15, 2026
PubMed
概括

机器学习通过分析DNA序列来预测金黄色葡萄球菌Cas9 (SaCas9) 活动. SaCas9的活性因其标序列内的腺甲基化而降低,这表明了进化防御机制.

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