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在施用化漆后唾液化物生物可用性:一项随机临床研究

Maria Suzi de Sousa Lopes¹, Lyzia Vitoria Mendes Rezende¹, Evanildo Canuto Paz¹

¹Federal University of Piauí, Department of Restorative Dentistry, Teresina, Piauí, Brazil.

Brazilian dental journal

|January 15, 2026

概括

这项研究比较了两种漆的化物生物可用性. 与Fluorniz相比,Duraphat®在唾液中显示出更高的化物可用性,而度在Fluorniz中更快地回到基线.

科学领域:

牙科材料科学牙科材料科学
口腔健康研究研究口腔健康研究
药理动力学药理动力学

背景情况:

化物漆 (FV) 对于预防牙至关重要.
了解化物在唾液中的生物可用性是优化疗效的关键.
化 (5%化) 是FV中常见的一种活性成分.

研究的目的:

评估和比较来自两个不同的5%化漆 (Duraphat®和Fluorniz) 的化物 (F) 的生物利用率.
在FV应用后,随着时间的推移,分析唾液区 (沉积物和浮沉物) 中的F度.
为了确定两个测试的漆之间的F释放动力学和总体可用性的差异.

主要方法:

一个随机的双相交叉临床研究,涉及15名参与者.
在牙上应用Duraphat®和Fluorniz,然后在多个时间点收集未受刺激的唾液 (基线至96小时).
使用t-测试,ANOVA和Dunnett的post hoc测试进行统计分析,以比较漆和时间点之间的F度和生物可用性.

主要成果:

在应用后,Duraphat®和Fluorniz都显著增加了唾液中的F度 (p < 0.001).
对于Duraphat®,F水平在24小时内恢复到基线,对于Fluorniz,F水平在8小时内恢复到基线.
与Fluorniz相比,Duraphat®在长达48小时的唾液区内显示出更高的F度,并且具有更高的总体F生物可用性 (p <0.05).

结论:

两种经过测试的化物漆都有效地增加了唾液化物水平.
与Fluorniz相比,Duraphat®具有更高的化物生物可用性和在唾液中保留.
这些发现表明配方影响化物释放特征和口服生物可用性的差异,影响着虫预防潜力.

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