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量身定制的多方面的药物护理干预措施的评估,以优化慢性阻塞性肺病管理:一个集群随机对照试验的协议

Xuedi Ma¹, Xiaocong Li², Xinyi Li²

¹Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

JMIR research protocols

|January 15, 2026

概括

本研究测试了一种数字工具支持的药剂师干预,以改善慢性阻塞性肺病 (COPD) 患者的健康相关生活质量 (HRQoL). 该干预措施旨在提高药物坚持和吸入器技术,以更好地管理疾病.

科学领域:

肺部医学肺部医学
医药护理医药护理医药护理
数字健康干预措施数字健康干预措施

背景情况:

慢性阻塞性肺病 (COPD) 患者通常由于药物坚持,吸入器技术和设备选择问题而缺乏疾病控制,影响与健康相关的生活质量 (HRQoL).
药剂师主导的干预措施,特别是那些使用数字工具并基于信息-动机-行为技能模型的干预措施,在改善慢性呼吸系统疾病的坚持和自我管理方面显示出希望.

研究的目的:

评估由药剂师领导的多方面的药物护理干预措施的有效性,在数字工具的支持下,改善中度至非常严重的COPD患者的HRQoL.
二级目标包括评估干预措施对药物坚持,整体生活质量,医疗保健成本和患者对药房服务的体验的影响.

主要方法:

这是一项为期一年的集群随机对照试验,涉及34家医院制药护理诊所,随机将患有COPD (GOLD阶段2-4) 和低于最佳的吸入器技术的参与者分为干预或常规护理.
干预组获得量身定制的支持,包括电子粘附监测,吸入器技术评估和数字工具辅助的峰值吸入流量测量,以优化设备.
使用线性混合效应模型分析结果,分组分析探索各种人口统计和生活方式因素的影响. 药房服务数据进行了定性分析.

主要成果:

该试验于2024年7月15日注册,招聘将于2025年12月31日完成,招收了454名参与者.
截至2025年12月31日,16名参与者 (3.5%) 完成了12个月的随访.
全试验预计将于2026年12月31日完成,预计结果将于2027年.

结论:

药剂师主导的,数字支持的药物护理干预提供了一个潜在的可扩展模型,用于增强COPD管理和改善患者HRQoL.
如果证明有效,这种干预措施可以在全国范围内的众多制药护理诊所广泛实施,使大量患者受益.

关键词:

慢性阻塞性肺病慢性阻塞性肺病集群随机对照试验集群随机对照试验与健康相关的生活质量.药物治疗的坚持药物治疗的坚持医疗保健医疗保健医疗保健

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