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Updated: May 7, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

Published on: April 11, 2025

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使用CRISPR/Cas9系统建立一个GPD1L淘汰人类胚胎干细胞系 (WAe009-A-80)

Tao Dong1, Yan Zhao2, Hai-Feng Jin1

  • 1Department of Anatomy, Histology and Embryology, Basic Medicine School, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China; Heilongjiang Provincial Key Laboratory of Food & Medicine Homology and Metabolic Disease Prevention, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China.

Stem cell research
|January 15, 2026
PubMed
概括

糖酸盐脱酶1-样 (GPD1L) 与布鲁加达综合征有关. 这项研究产生了GPD1L淘汰干细胞系,揭示了它在维持正常细胞功能和分化中的重要作用.

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相关概念视频

CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...