自然产品调节线粒体相关膜,以预防心血管疾病
Yuefang Zhang1, Bo Ning2, Weiwei He1
1Shaanxi University of Chinese Medicine, Xianyang 712046, China.
概括
天然产品通过向线粒体相关膜 (MAM) 来治疗心血管疾病 (CVD) 是有前途的. 这些天然产品提供了比传统疗法更安全的替代方案,突出了MAM作为一个关键的治疗目标.
科学领域:
- 细胞生物学 细胞生物学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心血管疾病 (CVD) 是导致死亡的主要原因,因衰老而恶化.
- 线粒体相关膜 (MAM) 对于线粒体和内分泌网膜 (ER) 之间的通信至关重要,它们的功能障碍与心血管疾病有关.
- 传统的心血管疾病治疗有局限性,这促使人们探索像天然产品 (NP) 这样的补充疗法.
研究的目的:
- 审查MAM在心血管疾病病理生理学中的作用.
- 探索MAM作为心血管疾病的治疗点.
- 检查NP如何调节线粒体-ER相互作用,并通过MAM发挥心脏保护作用.
主要方法:
- 系统审查过去五年 (至2025年8月) 发表的研究.
- 搜索术语包括"心血管疾病"",线粒体"",内分泌网膜"",线粒体关联膜"",天然产品"",传统中医药"和相关概念,如"线粒体动力学"",脂质代谢"","",亡"",自"",炎症"和"氧化应激".
主要成果:
- MAM在各种心血管疾病的发病过程中发挥着关键作用,包括动脉样硬化,心肌缺血/反损伤,心力衰竭和心律失常.
- 通过MAM相互作用维持正常的线粒体和ER功能是心血管保护的关键机制.
- 研究证实了MAM在心血管疾病发展和进展中的关键作用.
结论:
- 自然产品,包括传统中医药,通过向MAM,有效地缓解心血管疾病症状.
- 国家药物提供了有利的安全性概况,副作用的发生率很低.
- MAM是开发新型心血管疾病治疗的重要治疗目标,NP显示出相当大的潜力.
更多相关视频
07:14A Flow Cytometry-based Assay for Measuring Mitochondrial Membrane Potential in Cardiac Myocytes After Hypoxia/Reoxygenation
Published on: July 13, 2018
15.1K
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.9K
相关概念视频
Mitochondrial Membranes
16.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
16.6K
Electron Transport Chain: Complex I and II
18.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
18.5K
Atherosclerosis III: Management
322
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
322
The Inner Mitochondrial Membrane
4.5K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria. In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.5K
Mitochondria
19.6K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.6K
Mitochondrial Precursor Proteins
3.6K
Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70 chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial...
Most of the mitochondrial...
3.6K
