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鲁丁减轻了皮拉鲁比辛引起的心脏毒性,并增强了乳腺癌中的化学敏感性

Qi Li¹, Meng Qin², Ping Liu²

¹Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, No. 1558 Sanhuan North Road, Huzhou, 313000 Zhejiang Province, China; Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, No. 1558 Sanhuan North Road, Huzhou, 313000 Zhejiang Province, China; Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, 1266 Fujin Road, Changchun, Jilin 130021, China.

Phytomedicine : international journal of phytotherapy and phytopharmacology

|January 15, 2026

概括

鲁丁通过调节miR-129-1-3p/GRIN2D通路来保护皮拉鲁比辛的心脏毒性,并增强其在乳腺癌中的抗癌作用. 这一发现为更安全,更有效的化疗提供了一个新的治疗点.

科学领域:

生物医学科学生物医学科学
分子生物学分子生物学
在瘤学瘤学.

背景情况:

乳腺癌的Pirarubicin (THP) 化疗受剂量依赖性心脏毒性限制.
素是一种黄类化合物,对心脏保护和抗癌活性有希望,但其机制尚不清楚.

研究的目的:

研究miR-129-1-3p/GRIN2D轴在鲁丁的心脏保护和化学敏感作用中的作用.
阐明基于THP的化疗中,路丁的双重益处背后的分子机制.

主要方法:

使用了一种双重疾病的小鼠模型 (4T1乳腺瘤).
接受THP与或没有鲁丁或miR-129-1-3p的小鼠.
评估了心脏功能,氧化应激,心肌酶,平衡和瘤进展.

主要成果:

通过减少氧化应激,心肌细胞亡和恢复平衡,素减轻了THP诱导的心脏毒性.
鲁丁增强了THP的抗瘤功效,抑制了瘤生长和转移,同时增加了亡.
常规调节了miR-129-1-3p,它准并抑制了GRIN2D,减少了氧化应激和心脏和瘤组织中的过量.

结论:

鲁抗击THP心脏毒性,并通过miR-129-1-3p/GRIN2D通路改善化疗.
miR-129-1-3p是这个轴的关键中间体.
鲁丁-miR-129-1-3p-GRIN2D途径为提高乳腺癌化疗安全性和疗效提供了一个有希望的目标.

关键词:

乳腺癌乳腺癌乳腺癌的恒温稳定的恒温稳定心脏毒性有关心脏的毒性.一个常规的日常生活.在 miR-129-1-3p 中使用.

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