青少年大麻和酒精使用,神经认知表现和三重网络休息状态连接之间的关联
Sophia H Blyth1, Lauren D Hill1, Anna Huang1
1Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|January 15, 2026
概括
青少年使用大麻会影响默认模式网络 (DMN) 和执行控制网络 (ECN) 之间的大脑连接. 青少年的酒精使用与更好的认知表现有关,可能是由于社会经济因素.
科学领域:
- 神经科学是一个神经科学.
- 青少年发展 青少年发展
- 药物使用研究研究 药物使用研究
背景情况:
- 青少年吸毒,特别是酒精和大麻,与自杀,过量服用和执行功能障碍等风险有关.
- 静止状态网络 (默认模式网络,执行控制网络,突出网络) 的功能障碍连接与物质使用和认知缺陷有关.
- 关于物质使用对青少年三重网络连接 (DMN,ECN,SN) 的影响的研究有限.
研究的目的:
- 为了研究酒精和大麻使用与典型发育青少年的三重网络连接之间的关系.
- 在一个更大的青少年队伍中检查物质使用和执行控制功能之间的关联.
主要方法:
- 在费城神经发育队列 (n=520) 中使用回归模型来分析酒精和大麻的使用与三重网络连接,控制共变量.
- 在一个更大的数据集 (n=4197) 中检查了物质使用和执行控制之间的关系,其中包括神经认知和物质使用数据.
主要成果:
- 在FDR校正后,酒精使用与三重网络连接没有显著的关联.
- 更高的大麻使用量与默认模式网络 (DMN) 和执行控制网络 (ECN) 之间的连接性增加有显著联系.
- 较高的酒精使用与改善工作记忆,精神灵活性,注意力和执行效率/准确性相关,可能受到社会经济因素的影响;大麻使用与神经认知表现无关.
结论:
- 青少年吸食大麻与改变的DMN-ECN连接性有关.
- 青少年的酒精使用与更好的神经认知性能有关,可能是由于社会经济因素的混.
- 未来的研究应该探索针对DMN,ECN和SN的干预措施,以了解它们在连接性,认知和物质使用中的作用.
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