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circPTPRM可以编码一个功能性多,circPTPRM-187aa,以促进乳头甲状腺癌的进展

Chengzhou Lv¹, Jiapeng Huang¹, Xiaoyu Ji¹

¹Department of Thyroid Surgery, The First Hospital of China Medical University, No. 155 in Nanjing North Street, Heping Distinct, Shenyang, Liaoning Province, China.

Molecular and cellular endocrinology

|January 15, 2026

概括

循环RNA PTPRM (circPTPRM) 编码了一种促进乳头甲状腺癌 (PTC) 进展的多. 这种circPTPRM多通过激活TGF-β通路来增强瘤细胞的增殖,迁移和入侵.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

乳头甲状腺癌 (PTC) 是最常见的甲状腺癌,预后有所变化.
虽然循环RNAs (circRNAs) 具有已知的调节作用,但它们在甲状腺癌中的转化功能在很大程度上尚未被探索.

研究的目的:

调查PTC中circRNAs的翻译功能.
探索circPTPRM及其编码的多在PTC瘤发生中的作用及其潜在的分子机制.

主要方法:

定量实时PCR (qRT-PCR) 和光在位杂交 (FISH) 用于circPTPRM表达.
在体外和体内实验中使用敲击和过度表达载体来评估circPTPRM对PTC细胞的影响.
机理学研究包括免疫光学,质谱学,免疫沉和无处不在测试,以阐明涉及的分子通路.

主要成果:

发现circPTPRM通过其翻译的多胺影响PTC细胞的增殖,迁移和入侵.
在体内,circPTPRM的过度表达导致裸体小鼠模型中瘤体积和体重增加.
确定circPTPRM-187aa多结合IQGAP1,通过上调RAC1和CDC42来激活TGF-β通路,从而激活TGF-β通路.

结论:

可以将circPTPRM转化为circPTPRM-187aa聚.
circPTPRM-187aa通过调节IQGAP1和激活TGF-β信号通路来促进PTC进展,从而增强细胞增殖,迁移和入侵.

关键词:

循环的RNA是循环的RNA.在EMT中,EMT是EMT.在IQGAP1中,智商差距为1.乳头甲状腺癌是一种乳头甲状腺癌.翻译翻译翻译翻译

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