拉丁美洲人口中自杀思想和行为的基因组研究:系统性审查
Brenda Cabrera-Mendoza1, Alana Castro Panzenhagen2, Guillermo de Anda-Jáuregui3
1Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USA.
Biological psychiatry
|January 15, 2026
概括
拉丁美洲关于自杀倾向的基因组研究正在增长,但仍然分散. 更具代表性的抽样,祖先意识的方法和合作对于在这些代表性不足的人群中推进研究和预防至关重要.
科学领域:
- 遗传学和基因组学 在
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 自杀是一个重要的全球健康问题,拉丁美洲的自杀率正在上升.
- 拉丁美洲和西班牙裔/拉丁裔人口在自杀性基因组研究中代表性不足.
- 本综述综合了这些人群中自杀倾向的现有基因组证据.
研究的目的:
- 系统地审查和综合对拉丁美洲和西班牙裔/拉丁裔人口中自杀倾向的基因组研究.
- 识别与自杀行为相关的遗传,表观遗传和转录体标记的现有证据.
- 评估研究的现状,确定缺口和未来方向.
主要方法:
- 关于自杀倾向 (思想,企图,自我伤害,死亡) 的分子研究的系统审查.
- 在PubMed,SciELO,REDALyC和区域期刊中搜索相关研究.
- 对符合条件的研究进行叙述综合和元分析,包括偏见风险评估和共同作者网络分析.
主要成果:
- 59项研究包括:50项遗传,6项转录性,3项表观遗传,3项家族风险.
- 候选基因研究 (血清能,应激反应) 显示出不一致的结果;元分析没有发现关键标志物的显著关联.
- 全基因组和多基因研究确定了祖先特定的位置,但小样本和有限的资源阻碍了进展. 转录组/表观遗传学研究表明神经发育和免疫之间的联系.
结论:
- 拉丁美洲关于自杀倾向的基因组研究正在扩大,但缺乏力量和碎片化.
- 需要增加代表性抽样和祖先意识的方法.
- 促进合作对于推进研究和为这些人群制定有效的预防策略至关重要.
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