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相关概念视频

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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适应性智能水凝在病理环境中驱动精密骨愈合.

Hongkai Huang1, Tianhua Xiao2, Ying Li1

  • 1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, PR China.

Journal of controlled release : official journal of the Controlled Release Society
|January 15, 2026
PubMed
概括

适应性智能水凝为复杂的骨缺陷提供了动态,响应的解决方案,克服了传统疗法的局限性. 这些智能材料可实现精确的药物输送和免疫调节,以改善骨愈合.

关键词:
适应性智能水凝是适应性的智能水凝.骨再生 骨的再生动态监管机制 动态监管机制病理性的微观环境.

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科学领域:

  • 生物材料科学 生物材料科学
  • 再生医学是一种再生医学.
  • 纳米技术纳米技术

背景情况:

  • 由于敌对的微环境 (炎症,缺氧,酸化),病理性骨缺陷存在复杂的挑战.
  • 使用静态支架和被动药物释放的传统骨修复策略往往不足以准确,适应性干预.

研究的目的:

  • 审查适应性智能水凝用于骨修复,重点关注其动态调节机制和应用.
  • 突出这些水凝在解决特定病理性骨疾病和治疗目标方面的作用.

主要方法:

  • 对适应性水凝机制和在骨缺陷治疗中的应用进行系统审查.
  • 讨论影响水凝反应的物理和化学触发因素 (例如光,pH,酶).

主要成果:

  • 适应性水凝可实现空间时间控制的药物递送,降解,免疫调节和细胞调节.
  • 这些水凝在治疗糖尿病骨缺陷,骨瘤,骨质疏松症,关节炎和牙周炎方面表现有前途,通过精确的行动.

结论:

  • 适应性智能水凝代表了骨修复的范式转变,提供量身定制的治疗措施.
  • 未来的方向包括个性化的设计,多式联络整合和人工智能辅助的开发,以加速临床翻译.