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消毒的阿克尔曼西亚菌的安全评价 YGMCC264545 YGMCC264545

Jie Tian¹, Zhili He², Minlei Zhao²

¹Hubei Provincial Center for Disease Control and Prevention & NHC Specialty Laboratory of Food Safety Risk Assessment and Standard Development,Wuhan, 430079, China.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|January 15, 2026

概括

阿克尔曼西亚·穆奇尼菲拉 (A. muciniphila) YGMCC2645是安全的消费. 广泛的安全测试,包括毒性和基因毒性测定,没有显示任何不良影响,支持其作为食品成分的使用.

科学领域:

微生物学微生物学
益生菌益生菌益生菌
食品安全食品安全

背景情况:

阿克尔曼西亚菌 (A. muciniphila) 显示出潜在的健康益处,将其定位为有前途的下一代益生菌.
系统的安全评估对于A. muciniphila的开发和利用至关重要.

研究的目的:

进行一项全面的安全评估,对巴氏杀菌A. muciniphilaYGMCC2645.5.进行全面的安全评估.
为了确定A. muciniphila YGMCC2645作为食品成分的潜在使用的安全概况.

主要方法:

评估了抗生素耐药性,毒性和致病性基因.
在老鼠中确定了急性口服毒性 (LD50).
进行了基因毒性测试 (Ames,染色体异常,微核测试).
在老鼠中进行了90天的口服毒性研究.
在怀孕的老鼠中评估了产性毒性.

主要成果:

没有检测到抗生素耐药性,毒性或致病性基因.
急性口服LD50大于10.0g/kg BW (3.0×10^12 TFU/kg BW).这种情况发生在体内.
在任何测定中都没有观察到基因毒性.
在90天的口服毒性研究中,没有发现与治疗相关的不良影响.
产性毒性研究显示,对生殖或胎儿发育没有显著影响.

结论:

消毒A. muciniphila YGMCC2645在所有测试参数中显示出强大的安全性.
这些发现支持A. muciniphila YGMCC2645作为食品成分的安全性.

关键词:

A. muciniphila YGMCC264545 这种类型的虫子.益生菌益生菌是一种益生菌.安全评价安全评估

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