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职业暴露诱导氧化应激,肺功能障碍和运动能力降低:一个跨部门研究

Ukbe Sirayder¹, Cihangir Acik¹

¹Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Nuh Naci Yazgan University, Kayseri, Kocasinan, Türkiye.

Toxicology letters

|January 15, 2026

概括

职业暴露显著损害了运动能力和肺功能,氧化应激发挥了作用. 累积暴露时间是这些负面健康影响的关键预测因素.

科学领域:

环境健康环境健康
职业医学职业医学是专业的.
毒理学毒理学毒理学

背景情况:

职业暴露是一个重大的公共卫生问题.
毒性可以影响多个器官系统.
之前的研究表明对生理功能的潜在影响,但缺乏全面的多系统评估.

研究的目的:

评估职业暴露对运动能力的影响.
调查氧化应激在诱导的生理变化中的作用.
评估暴露于的工人的肺功能影响.

主要方法:

横截面研究涉及48名暴露于的男性工人和51名对照男性工人.
使用增量穿步行测试 (ISWT) 评估运动能力.
通过螺旋计测量肺功能,血水平 (ICP-MS) 和氧化应激标志物 (MDA,FRAP) 的测量.

主要成果:

暴露于的工人表现出显著减少的ISWT距离,增加呼吸困难和疲劳,以及减少FRAP的MDA升高.
暴露组中观察到强迫生命能力 (FVC) 的显著减少.
暴露的持续时间是运动能力降低,呼吸障碍增加,疲劳和FVC降低的重要预测因素.

结论:

职业暴露会对运动表现和肺功能产生不利影响.
氧化应激导致这些损伤,累积暴露时间是关键因素.
这项研究通过整合运动,生物化学和呼吸系统参数,为暴露的系统生理负担提供了新的见解.

关键词:

抗氧化剂是一种抗氧化剂.运动测试运动测试中毒中毒是什么职业暴露职业暴露肺功能肺功能肺功能

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