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甘 lucidum 多糖的保护作用对抗西斯普拉丁诱导的毒性
Zumin Hou1, Weiling Ji2, Shangpeng Yang1
1Key laboratory of molecular pharmacology and translational research, School of Pharmacy, Shandong Second Medical University, Weifang 261053, Shandong, China.
Journal of ethnopharmacology
|January 15, 2026
概括
甘白 (GL-PP和GL-PP2) 可以在多个器官中防止西斯的毒性. 通过特定的信号通路,GL-PP2通过减少炎症,氧化应激和亡来证明卓越的疗效.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品研究自然产品研究
- 细胞和分子生物学 细胞和分子生物学
背景情况:
- 光 (G. lucidum) 是一种传统的中医药,有着用于活力和器官支持的历史.
- 它的提取物以免疫调节和抗氧化特性而闻名,使它们对器官保护有兴趣.
- 传统上,G. lucidum一直用于治疗慢性炎症,疲劳和毒素引起的器官损伤.
研究的目的:
- 调查G.lucidum多糖 (GL-PP) 和G.lucidum多糖2 (GL-PP2) 对西斯 (CDDP) 诱导的多器官毒性的保护作用.
- 探索GL-PP和GL-PP2在缓解CDDP诱导的毒性方面的潜在作用机制.
主要方法:
- 采用体内和体外模型来评估器官保护.
- 评估了关键的生化指数,组织学变化,氧化应激,炎症,纤维化和亡.
- 利用网络药理学和西方涂抹来阐明分子机制.
主要成果:
- GL-PP和GL-PP2改善了心脏,肝脏和功能,减少了CDDP引起的损伤和纤维化.
- 通过激活Akt/GSK-3β/Nrf2通路,GL-PP2 (200 mg/kg) 显示出显著的抗炎和抗氧化作用.
- 调节关键的亡相关蛋白质,包括BCL-2,BAX和分裂的caspase-3.
结论:
- GL-PP和GL-PP2提供了对CDDP毒性的多器官保护.
- 保护主要通过激活Akt/GSK-3β/Nrf2信号通路来实现.
- 与GL-PP相比,GL-PP2显示出更高的保护效率.
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