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在美国,两种基于人口的系统性红斑狼成年人群中,感知和客观的身体功能

Laura C Plantinga¹, Jessica Fitzpatrick², Mrinalini Dey³

¹L.C. Plantinga, PhD, Associate Professor, Divisions of Rheumatology and Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

The Journal of rheumatology

|January 15, 2026

概括

在全身性红斑狼 (SLE) 中,感知到的身体功能可能与目标身体功能不一致. 诸如老年和较高的疾病活动等因素会影响这种不一致.

科学领域:

类风湿病学类风湿病学
流行病学流行病学
老年学是一门学科.

背景情况:

系统性红斑狼 (SLE) 显著影响患者的生活,身体功能是关键问题.
了解患者如何看待他们的身体功能和他们实际的目标身体功能之间的关系对于有效的管理至关重要.
感知和客观身体功能之间的差异可能会影响治疗决策和患者报告的结果.

研究的目的:

在两个SLE群体中估计感知和客观的身体功能.
识别与感知和客观身体功能相关的因素.
调查SLE患者感知和客观身体功能之间的不一致性.

主要方法:

利用了来自"积极的,以患者为中心的狼衰老经验方法" (APPEAL) 和"加利福尼亚狼流行病学研究" (CLUES) 队列的数据.
使用PROMIS物理功能得分和使用短物理性能电池 (SPPB) 的客观物理功能评估感知到的身体功能.
采用多项逻辑回归来识别与感知和客观物理函数得分之间的不一致相关的因素.

主要成果:

在APPEAL和CLUES队伍之间观察到的感知和客观身体功能的显著差异,受种族和年龄的影响.
高龄,黑人种族和较高的疾病活动与较低的感知和客观身体功能有关.
大约22.3%的参与者表现出不一致的分数,年龄较大和较高的疾病活动与高估体能的可能性较低有关.

结论:

感知和客观的身体功能在SLE群体中表现出相当大的变化,受患者特征的影响.
感知到的身体功能并不总是反映SLE患者的客观身体功能.
需要进一步的研究来探索这种不一致性在SLE管理中的临床影响.

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