儿童抑郁症状,焦虑和心理压力中的性别差异 在患儿类类风湿性疾病的儿童和青少年中
Rachel L Randell1, Kaveh Ardalan2, Nicole B Carson3
1R.L. Randell, MD, MSCR, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA.
The Journal of rheumatology
|January 15, 2026
概括
患有青少年异常性关节炎 (JIA) 和全身性红斑狼 (cSLE) 的女孩报告的抑郁症,焦虑和心理压力的症状比男孩更高. 心理健康中的这些性别差异即使在考虑了疾病活动后仍然存在.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 儿童和青少年心理健康
背景情况:
- 青少年异常性关节炎 (JIA) 和全身性红斑狼 (cSLE) 是影响儿童和青少年的慢性类风湿性疾病.
- 精神健康并发症,包括抑郁症,焦虑症和心理压力,在这些儿科群体中很常见.
研究的目的:
- 评估JIA和cSLE诊断的儿童和青少年中抑郁症,焦虑症和心理压力症状的性别差异.
- 为了确定这些特定的儿科类风湿性疾病中基于性别的心理健康结果的潜在差异.
主要方法:
- 一个多中心的前性队列研究,涉及儿童和青少年从儿童关节炎和风湿病联盟注册.
- 收集疾病活动和患者报告结果测量信息系统® (PROMIS) 儿童自我报告措施,用于12个月的抑郁症状,焦虑和心理压力.
- 使用基平方,威尔科克森等级总和测试和线性混合效应模型进行统计分析,以评估基于性别的差异.
主要成果:
- 与男孩相比,患有JIA和cSLE的女孩在抑郁症状,焦虑和心理压力方面的得分显著更高.
- 在基线,女孩的比例高于男孩,经历了中度至重度的抑郁症状和心理压力.
- 在调整了疾病活动,时间和其他相关因素后,这些基于性别的心理健康症状差异仍然很大.
结论:
- 在JIA和cSLE的背景下,女孩总是报告比男孩更糟糕的心理健康症状 (抑郁,焦虑,心理压力).
- 观察到的心理健康的性别差异是强大的,并且独立于类风湿性疾病的活动.
- 临床实践应考虑根据性别为患有JIA和cSLE的儿科患者量身定制心理健康查,管理和干预措施.
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