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来自红杉的氧黄A增强了Caenorhabditis elegans中的应激弹性和蛋白质静止

Linyao Jing¹, Zhaoxin Zhang¹, Zhixia Zhang¹

¹National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.

Food research international (Ottawa, Ont.)

|January 15, 2026

概括

来自红杉的氧黄A (HSYA) 显著延长了寿命,并增强了C. elegans的抗压能力. 这种天然化合物增强了抗氧化防御和蛋白质稳定,显示了针对衰老和神经退行性疾病的功能性食物的潜力.

科学领域:

生物化学生物化学
老年学是指老年学的学科.
分子生物学分子生物学

背景情况:

饮食中的生物活性化合物被认为有助于促进健康的衰老和细胞保护.
水氧沙黄A (HSYA) 是来自红杉的石墨烯糖化物,是一种具有潜在的功能性食品应用的天然色素.

研究的目的:

研究HSYA对Caenorhabditis elegans (C. elegans) 的寿命和抗压力的影响.
阐明HSYA有益作用的潜在分子机制.

主要方法:

在C. elegans的正常,热和氧化应激条件下的寿命测定.
在C. elegans模型中分析基因表达 (DAF-16,HSF-1,HSPs) 和蛋白质聚合.
测量抗氧化酶活动 (SOD,POD,GST) 和活性氧物种水平.

主要成果:

在各种压力条件下和正常衰老下,HSYA显著延长了C. elegans的寿命.
HSYA促进了DAF-16核转位,调高了热冲击蛋白质,并激活了未折叠的蛋白质反应和自.
在神经退行性模型中,HSYA通过增加酶活性和减少活性氧物种来增强抗氧化能力,并减轻了蛋白质聚合.

结论:

在体内,HSYA表现出强大的抗氧化和蛋白质稳定调节活性.
HSYA显示出作为一种功能性食品成分的潜力,可以促进健康的衰老,并对抗与年龄相关的疾病,包括神经退行性疾病.

关键词:

抗衰老的抗衰老的抗衰老的这是一种抗压力药,可以减轻压力.凯诺哈比迪斯的优雅的植物.在HSYA中,HSYA是最重要的.胰岛素/胰岛素生长因子1 (IGF-1) 信号通路不折叠的蛋白质反应 (UPR)

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