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作为益生菌调节剂的分子重量工程的lentinan分数:为精确的肥胖干预指导肠道微生物群

Xiang Yan¹, Yi Shen¹, Qi Tao¹

¹College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, China.

Food research international (Ottawa, Ont.)

|January 15, 2026

概括

来自Lentinula edodes的Lentinan分数显示出预防肥胖的潜力. 它们的分子量影响肠道微生物群,促进有益的细菌和产生关键酸,为精密营养提供基础.

科学领域:

微生物学微生物学
营养科学营养科学
生物化学生物化学

背景情况:

伦丁多糖,特别是伦丁,以与肠道微生物群相互作用相关的健康益处而闻名.
肠道失调与肥胖有关,突出显示了微生物群调节干预措施的必要性.

研究的目的:

研究水溶性伦丁 (WSL) 的三个分子量 (Mw) 分数对健康和肥胖个体的肠道微生物群的体外影响.
评估WSL部分在预防饮食引起的肥胖和减轻肠道失调症方面的潜力.
确定lentinan的Mw梯度是否起到肠道微生物群的定向调节者的作用.

主要方法:

利用了健康和肥胖个体的肠道微生物群的体外发酵模型.
研究了水溶性伦丁的三个不同的分子量分数:WSL-40 (2.19 × 10^6 Da),WSL-60 (2.96 × 10^5 Da) 和WSL-80 (1.70 × 10^4 Da).
分析了微生物组成的变化,包括特定的属和Firmicutes/Bacteroidetes比率,并测量了黄油酸的产量.

主要成果:

在健康的微生物群中,WSL-80促进了Parabacteroides的生长和最大的黄油酸生产,表明了预防肥胖的潜力.
在肥胖微生物群中,WSL减轻了失生症,较低的Mw分数逐渐降低了Firmicutes/Bacteroidetes比率.
WSL-80增加了Phascolarctobacterium和Klebsiella,WSL-60和WSL-80增加了Bacteroides,WSL-40增加了Weissella. WSL-80增加了Phascolarctobacterium和Klebsiella,WSL-60和WSL-80增加了Bacteroides,WSL-40增加了Weissella. WSL-80增加了Phascolarctobacterium和Klebsiella,WSL-60和WSL-80增加了Bacteroides,WSL-40增加了Weissella.

结论:

伦提南的分子量梯度作为功能性肠道微生物群的定向调节器.
这些发现为在精准营养策略中使用lentinan分数来对抗肥胖提供了理论基础.
这项研究表明,lentinan对肠道微生物群的组成和功能产生了Mw-依赖的影响.

关键词:

我们的肠道微生物群.兰丁虫 (Lentinula edodes) 是一种有毒的植物.这就是为什么MW Mw Mw.肥胖问题肥胖问题在水中溶解的lentinan lentinan.

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