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Updated: Jan 17, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Published on: February 17, 2022

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在BCMA CAR-T细胞治疗后,CD4+ T细胞调解CAR-T细胞相关的免疫相关不良事件

Matthew Ho1,2,3, Luca Paruzzo1,2,3,4, Julia Han Noll2

  • 1Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nature medicine
|January 15, 2026
PubMed
概括

针对B细胞成熟抗原 (BCMA) 向的化学抗原受体 (CAR) T细胞疗法会导致独特的毒性,称为CAR T细胞疗法相关的免疫相关不良事件 (CirAEs). CD4+ CAR T 细胞扩张与这些严重事件有关,增加死亡风险.

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