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准备和评价Candesartan Cilexetil固体超和自纳米乳液含有脂的准备和评价

Kai Zheng¹, Tianyi Wang¹, Hao Chen¹

¹School of Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang, 110016, China.

AAPS PharmSciTech

|January 16, 2026

概括

一种新的固体超和自纳米乳化药物递送系统 (固体PC-S-SNEDDS) 显著提高了candesartan cilexetil (CC) 的溶解性和生物可用性. 这个创新的系统超越了CCCC.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

坎德沙坦西莱克塞特 (CC) 溶解性差,具有显著的第一通效应和低口服生物可用性.
传统配方努力克服这些局限性,影响治疗疗效.

研究的目的:

开发和描述一种新的固体超和自纳米乳化药物输送系统 (固体PC-S-SNEDDS),以改善CC输送.
评估脂和沉抑制剂对CC可溶性,稳定性和生物利用性的影响.

主要方法:

使用中央复合设计和单因素调查,制定SNEDDS,S-SNEDDS,PC-S-SNEDDS和固体PC-S-SNEDDS.
使用PXRD和FT-IR进行表征,以确认无形药物状态和没有新的化学键.
在体外溶解研究,稳定性测试,大鼠的药物动力学研究和淋巴运输实验.

主要成果:

固体PC-S-SNEDDS配方与CC和销售囊相比,显示出显著增强的溶解率和累积溶解.
PXRD和FT-IR证实了CC在固体PC-S-SNEDDS中的无形状态,没有与辅助剂的化学相互作用.
药理动力学研究表明,CC生物可用性显著增加 (568.17%的CC悬浮液,415.00%的营销囊) 和增强的淋巴运输 (62.14%对18.69%).

结论:

固体PC-S-SNEDDS有效地提高了CC的溶解性,并减少了第一通效应.
这种先进的药物递送系统显著提高了CC的口服生物可用性和淋巴运输.
固体PC-S-SNEDDS提出了一个有前途的战略,以克服与candesartan cilexetil相关的药理学挑战.

关键词:

坎德沙坦 (candesartan) 是一种西莱克塞提尔.淋巴运输是指淋巴运输的过程.脂质是一种脂质.固体超和自我纳米乳液.可溶性和生物可用性.

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