相关实验视频

Updated: Jan 18, 2026

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Published on: June 21, 2011

从血液流向瘤细胞内化:纳米粒子动力学的多阶段计算模型

Álvaro González-Garcinuño^1,2, Eva Martin Del Valle^3,4, Sasa Kenjeres⁵

¹Department of Chemical Engineering, University of Salamanca, Plaza Los Caídos s/n, 37008, Salamanca, Spain. alvaro_gonzalez@usal.es.

Pharmaceutical research

|January 16, 2026

概括

这项研究开发了一种计算模型,用于从注射到瘤细胞吸收的纳米粒子运输. 功能化纳米颗粒与连接体受体相互作用改善了瘤向的50%.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
计算建模计算建模

背景情况:

纳米粒子 (NP) 运输和瘤组织分布对纳米医学至关重要.
现有的研究缺乏整个NP旅程到细胞的综合模型.

研究的目的:

开发一个计算框架模拟NP运输从管理到瘤细胞内化.
调查影响NP生物分布和瘤向的因素.

主要方法:

一个COMSOL多物理框架模拟了血流中的NP运动,跨内皮体运输和瘤流层运动.
结合了连接体-受体相互作用和生理瘤多孔性.
案例研究分析了粒子密度,注射速度和尺寸的影响.

主要成果:

该模型成功模拟了NP运输的所有阶段.
它是第一个包括纳米粒子亲和力用于通过连接体-受体相互作用的向传递的模型.
低斯托克斯数对于毛细血管网络的透至关重要;带功能化提高了准率50%左右.

结论:

开发了NP分布的综合计算模型,包括细胞识别.
这种模型促进了针对癌症治疗的纳米粒子行为的理解.

关键词:

在 CFD 交易中,我们可以看到 CFD.亲和力是一种亲和力.纳米颗粒跟踪跟踪运输建模运输建模瘤的环境瘤的环境

更多相关视频

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors

Published on: August 18, 2016

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow

In Vitro 3D Cell-Cultured Arterial Models for Studying Vascular Drug Targeting Under Flow

Published on: March 14, 2021

相关概念视频

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...